908 Devices Stock: Pure Play in Mini Mass Spectrometers

Butterfly Network (BFLY) is a company that we’ve liked ever since first writing about its handheld ultrasound device more than six years ago while reviewing some of the top AI startups in healthcare. While the technology is complicated, the concept is pretty simple: Shrink the capabilities of an ultrasound machine down to the size of a typical scanner used at the grocery store and pair it with a smartphone and machine-learning algorithms. Let the disruption begin. 

But though we liked the premise, the company’s decision to go public by merging with a special purpose acquisition company (SPAC) was something of a turn off. After the dust had settled, it was apparent that Butterfly Network overpromised on revenue, sending stock shares on a steep decline. The thesis is still sound – disrupting the market with a cheaper, idiot-proof piece of hardware – but our overall portfolio is already heavy on large medical device companies. In addition, the total addressable market (TAM) seems small and the competition pretty big. 

One person who is still bullish on Butterfly Network is Cathie Wood, the Moses of Ark Invest, an investment management firm that specializes in disruptive tech stocks. BFLY is currently the No. 18 largest holding in the ARK Genomic Revolution ETF (ARKG), with about $2.4 billion in assets under management.

The trajectory of Ark Invest's acquisition of 908 Device stock.
The trajectory of Ark Invest’s acquisition of 908 Device stock. Credit: cathiesark.com

Today, Ark Invest owns about 6% of Butterfly Network after continuing to add to its position over the last few months. At No. 17 in the ARKG portfolio is a company called 908 Devices (MASS) in which Ark Invest has a 10% stake. Let’s part the Red Sea of losses – Wood’s current cost basis is twice what MASS shares are currently trading – and see if there is any long-term potential for retail investors.

About 908 Devices Stock

The value proposition behind 908 Devices is identical to Butterfly Network, but rather than disrupting the market for ultrasound machines, the Boston-based company is shrinking the technology that powers mass spectrometers by developing handheld and desktop instruments. Founded 10 years ago, 908 Devices raised a modest $67 million in disclosed funding, but with a couple of particularly notable names. One is the venture arm of Saudi Aramco, which just happens to be the biggest company in the world by market cap at nearly $8 trillion. In fact, the gas and oil giant participated in three different funding rounds. The other is In-Q-Tel, which is basically the venture arm of the CIA. The CIA’s interest in 908 Devices will become clear shortly.

Unlike Butterfly Network, 908 Devices had a traditional IPO in December 2020 – the last company to go public that year. At the time, the company raised more than $136 million in an upsized offering and ended the day up more than +127%. Of course, those heady days are well behind us, with the stock down about 75% since it premiered on the public markets. Its market cap is just north of $500 million. Of course, we know the market is particularly punishing tech stocks right now, so let’s not get too caught up in the past and see where 908 Devices is going.

What is a Mini Mass Spectrometer?

Mass spectrometry – or mass spec, as the dorks cool kids refer to it – is an analytical technique used to characterize everything from small molecules to complex proteins. A mass spectrometer is sort of like a super fancy scale that measures the mass (hence, the name) of these particles through some scientific hocus pocus using ionization and electric currents that we won’t bother to dive into too deeply here. Basically, these highly sensitive machines can detect, identify, and quantify just about any molecular sample based on its molecular weight. The key takeaway is that most mass spec machines today are very large, expensive, and highly complex. Think mainframe computer size. In contrast, 908 Devices has developed both handheld and desktop versions of these massive machines.

Size of conventional mass spectrometer versus 908 Devices mass spec.
Credit: 908 Devices

The company refers to its proprietary technology, first developed at Oak Ridge National Laboratory, as high-pressure mass spec (HPMS), which enables it to miniaturize key components using semiconductor microfabrication techniques. For example, something called the ion trap, which is where ionized particles are sorted and manipulated under vacuum, is one thousand times smaller than those in conventional laboratory mass spec instruments. A typical vacuum system alone weighs hundreds of pounds and requires several hundred watts of power 24 hours a day. 908 Device’s mass spec instruments use less power than a 20-watt LED light bulb. Incidentally, the name of the company is a reference to 0.908, which is the “point of stability and instability within ion trap mass spectrometers – the point at which the magic happens!” Um, OK. Moving on …

Mass Spectrometers from 908 Devices

Awkward nerdy name aside, 908 Devices has introduced two flagship mass spec products that combine its HPMS platform, a proprietary sample preparation and separation technology called the ZipChip, and machine learning techniques to both control the hardware and interpret the data.

Mass spectrometer from 908 Devices
Credit: 908 Devices

Launched in 2017, the MX908 is a handheld, battery-powered, mass spec device designed to rapidly analyze gas, liquid, and solid materials in the field. Yes, this is the tricorder that Star Trek promised us all those decades ago when Capt. Kirk was galivanting around the galaxy banging blue chicks. It can detect trace quantities of more than 150 dangerous materials, including drugs, explosives, and hazardous chemicals with “sensitivity comparable to existing field-based technologies.” The company claims that “compared to a leading transportable mass spec product, the MX908 is up to 15x faster, up to 10x smaller, and up to 2x cheaper.” Its machine-learning software can help interpret and extrapolate results. For example, the MX908 is pre-programmed to evaluate a dozen of the most common fentanyl variants and then uses machine learning to look for patterns suggestive of the more than 2,000 fentanyl analogs.

The easy-to-use interface for the MX-908
The easy-to-use interface for the MX-908. Credit: 908 Devices

The Rebel, a small desktop mass spec introduced in 2019, can reputedly perform on par with high-performance liquid chromatography (HPLC) instruments in a laboratory, but at a price per sample that is up to 10 times lower, a third of the capital cost, and up to 2,000 times faster. The devices have various R&D applications related to pharmaceuticals and biotech, particularly around cell and gene therapies, synthetic biology, and more.

The Market for Mini Mass Spec Instruments

Indeed, 908 Devices believes that the cell and gene therapy industry, along with related applications such as the new generation of nanotechnologies turning cells into micro-factories, will be the driving force behind expanding its TAM in the near future from a pretty modest $5 billion today to $22 billion in just a handful of years. We encountered a similar projection from companies in another pick-and-shovel play, cold storage logistics, for cell and gene therapy.

Total addressable market for mini mass spectrometers.
Credit: 908 Devices

For handhelds, the company believes the market will more than double from $1.5 billion to $3.6 billion with software application extensions into quality assurance and quality control for things like inspecting raw materials and detecting adulterated materials. The much bigger leap of faith is in the desktop Rebel for bioprocessing and research.

908 Devices isn’t the only firm developing desktop mass spectrometers. MOBILion Systems has taken in $116 million in funding from names like Agilent (A) and IP Group (IPO.L). The firm specializes in identifying and analyzing challenging molecules that other instruments so far have failed to detect. Fierce Biotech had the following to say about their product offering – Mobie – in an article which talked about their latest funding round, a $60 million Series C raised last July.

Mobie combines MOBILion’s high-resolution ion mobility technology with Agilent Technologies’ mass spectrometers and Protein Metrics’ analysis software, resulting in a supercharged take on the molecular analysis workflow that’s meant to be faster and more accurate than standalone mass spectrometers.

Credit: Fierce Biotech

Should You Buy 908 Devices Stock?

We call it a leap of faith because the company mainly relies on the MX908 for the majority of its revenue, compared to its desktop devices, Rebel and ZipChip. The latter two are also where the company expects to grow recurring revenues through the proprietary consumables that the machines require to operate. Consumables accounted for 19% of product revenue in 2021, up from 14% the year before. Overall annual revenue growth was up an impressive 64% year-over-year.

908 Devices 2021 revenue by category.
Credit: 908 Devices

The mix is definitely changing as well. In H1-2022, revenue grew 40% but desktop revenue growth hit 52%. Another encouraging number for a company heavily reliant on hardware sales was a 60% gross margin as of Q2-2022. In addition, 908 Devices acquired a German company called TRACE Analytics for $15.3 million. TRACE Analytics provides online analysis and sampling systems for biotech applications, a technology to help customers build connected bioprocessing and analytics systems. 

There are all great metrics and moves, but let’s put some additional context around these numbers. 908 Devices has sold all of 2,100 or so instruments. And while it counts all 20 of the top 20 pharmaceutical companies by revenue among its 450 customers, most of its sales rely on government agencies. In addition, one customer accounted for a whopping 43% of total revenue last year. That’s a huge amount of customer concentration risk.

908 Devices revenue by customer type.
Credit: 908 Devices

Factor in the company’s small market cap and currently modest total addressable market, and you come up with a pretty low ceiling for future growth unless 908 Devices can really deliver its disruptive technology at a global scale. At this stage of the game, that potential remains debatable and with too much risk for our taste. 

For those who want to pull the trigger on some shares, 908 Devices has a simple valuation ratio of around 11. Here’s how that compares to other popular life sciences stocks in our disruptive tech stock catalog.

Asset NameNanalyze Valuation Ratio
Guardant Health13
Butterfly Network12
908 Devices11
Pacific Biosciences10
Oxford Nanopore9
iRhythm Technologies9
10X Genomics7
Teladoc Health2
Credit: Nanalyze


Companies like 908 Devices and Butterfly Network have developed game-changing technologies that could potentially reshape their respective industries. The challenge is that these are relatively small, niche markets. 908 Devices does make a more compelling case, especially if its mini mass spectrometers prove to be the sort of pick-and-shovel R&D play that it outlines for cell and gene therapies, precision fermentation, and other emerging applications for analyzing and characterizing cells. That might put it closer to the likes of companies like Illumina (ILMN) with its ground-breaking gene-sequencing technology and $37 billion market cap. 

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4 thoughts on “908 Devices Stock: Pure Play in Mini Mass Spectrometers
  1. Keep in mind the subsector of healthcare. In this life science tools space, a company needs to reach $100mn in revenue before you can fully appreciate the sustainability of their financial growth/outlook, see leverage in the model, and know if the product has staying power in the field. The cautionary tales are out there: Berkeley Lights got to $85mn before we found of their machine is a mothball that bamboozled tons of customers. Also keep in mind the hub and spoke model that’s needed for robust growth in perpetuity: everyone wants to be the next Illumina, but ILMN’s growth was enabled by the robust diagnostics industry that utilized its NGS tools and will continue to do so despite impending “competition.” 10x Genomics checks a bunch of the marks your team looks for and has well surpassed the $100mn mark in revenue that I commented on, but have they built out use cases for single cell analytics that will enable ILMN type growth for years to come? – yet to be seen but the market is saying no for now. Recurring revenue is the name of the game and your team rightly points that out when conducting diligence on this space. But recurring revenue in this space does not always need to be associated with hardware sales – which is a tough sell to customers when the price tags range from $300k to $3mn per machine. To that end, I’d encourage you to revisit diligence on Olink and Twist Bio – both companies don’t sell hardware but rather inputs/consumables. Olink is emerging as the winner in the proteomics space, very importantly able to leverage the massive install base of Illumina sequencers that can be used to run Olink’s panels (do I smell an acquisition in 2024 after the Grail saga subsides and ILMN sees they chose the wrong partner in Somalogic?) The proteomics field is early and still needs to build out an ecosystem of uses cases (especially for diagnostics – which is happening), but it is going to be an important field going forward. Twist’s DNA is going to be a key input into many of the diagnostic assays used in liquid biopsy testing for early cancer detection, residual cancer detection, biomarker testing. Sure, there is competition, but TWST has an edge in speed, cost, and quality. They need to improve the gross margin profile and convince investors that they are serious about reaching profitability within the next few years (the alternative being serial dilution that no real investor is interested in), but the applications for DNA as an input abound. Neither company is cheap, but in any technological innovation in the stock market, you overpay for quality and you underpay for garbage. I make the $100mn revenue comment because the biotech, pharma, clinical research, early science discovery fields see massive cash flow throughout, so there are going to be many early adopters who then encourage some of the late adopters to dole out some dough for the hot new thing, only to realize within a few years that they don’t really glean enough insight or utilize the tools enough to justify the hefty price tags. The financial departments in labs and companies want to make their scientists happy with new toys only to the extent that those tools can lead to something financially promising in the future. Companies that see impressive growth (20-30%+) y/y in 2022 and 2023 are the future leaders and ones to bet on. Every company saw growth in 2020/2021 because there was just that much capital flowing through a massively stimulated booming economy. The real winners make themselves clear when budgets are being bootstrapped and only necessities receive priority. No one can call a bottom in the market, but when the market starts to be confident that inflation is under control and the Fed no longer needs to engage in rate hikes, the growthier parts of the market will react quickly. That’s not to say though that profitability will become an afterthought again, as was the case from 2016-2021. Olink, Twist, and any other growing tech company can keep on growing and taking market share but not be rewarded if they don’t demonstrate leverage in the model (aka a path to profitability by having expenses be less as a percentage of revenue quarter by quarter or at least year by year). You guys do great work – keep it up.

    1. Thank you for the encouraging words and for an extremely insightful comment. Loved this line – “The real winners make themselves clear when budgets are being bootstrapped and only necessities receive priority.” We’re actually long Twist so agree with your comments there. Will need to watch their runway. Here’s the latest piece we did on Twist earlier this year – https://www.nanalyze.com/2022/01/challenges-twist-bioscience-stock/

      As for Olink, we revisited them late this summer in this piece in the broader proteomics space (https://www.nanalyze.com/2022/08/seven-proteomics-stocks-best-one/). We concluded that “we maintain the belief that Olink needs to see revenue from kits at least match services before we’d take a serious look at the company.” There is some concern that they may be utilizing budgets that will dry up per our comments in the piece. Interesting suggestion about Illumina eyeballing them as a potential growth avenue once the Grail fiasco clears up. Really appreciate you taking the time to share some quality insights!

  2. ARK: “Shares of 908 Devices traded down ~22% and ~15% on Monday and Tuesday, respectively, after the company reported third-quarter results. While 908 Devices surpassed expectations for both revenue and margins, investors reacted negatively to lower-than-expected revenue guidance based on macroeconomic headwinds. ”
    908 Devices share price fell from $16 (at the time of this article 3 weeks ago) to $9.90 now.

  3. 2 months passed since this article and the stock fell over 50%.
    The stock started trading end of 2020 at around $60, now is $7.45. Markt cap: $236M.
    The question is: does the stock deserve that kind of punishment ?
    In November they reported Q3 revenue $15.8M (+26%). They have $193M in cash – that is close to their market cap ..
    2022 guidance: revenue range expected to $46M-49M representing growth of 13% over 2021.

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