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7 AI Cancer Diagnostics Startups Digitizing Healthcare

The world seems more divided today than ever, whether we’re talking about politics or the questionable art form of twerking. However, there’s one thing we can all agree on: cancer sucks. Nearly 40% of us will receive the dreaded diagnosis at some point in our lives, according to the National Cancer Institute. That’s one reason why we’ve spent quite a bit of time writing about the topic, particularly the different technologies being developed to detect various forms of the disease. It’s really a no-brainer: Data from Cancer Research UK suggests 80% of patients survive for at least 10 years after being diagnosed in the early stages of eight of the most common cancers. Genetic tests and liquid biopsies are among the emerging diagnostic tools that we’ve covered previously, most recently with our piece on 9 Genomics Startups for Investors to Watch. In this article, we want to highlight the advances being made in AI cancer diagnostics for digitizing healthcare in pathology, radiology, and elsewhere.

Earlier this month we talked about how much money is being invested into healthcare startups that are working on artificial intelligence, with the bright minds at data research firm CB Insights estimating that those companies have raised more than $1.4 billion in the first half of 2019 alone. We’ve written about quite a few of these startups, from those employing AI for drug discovery to simulating cancer cells using AI. The leading category by far is in AI diagnostics and imaging technology. Algorithms are getting particularly adept at identifying anomalies in medical imagery, and that’s where we’re seeing many AI healthcare startups finding success in oncology diagnostics.

An Operating System for Battling Cancer

Click for company websiteLet’s start with Tempus, a Chicago-based startup that has raised a whopping $520 million since it was founded in 2015. The company most recently pocketed $200 million from a Series F in May. You’re probably more familiar with one of billionaire founder Eric Lefkofsky’s other ventures – Groupon (GRPN). His latest company is no bargain at a valuation of $3.1 billion. Tempus is creating what it calls an operating system to battle cancer using big data and a subset of AI called machine learning. More specifically, Tempus combines genomic sequencing of tumors, AI-powered tools to structure diverse datasets like oncology notes and pathology reports, and machine-learning algorithms fine-tuned to analyze radiology and pathology images. The result, the company contends, is a data-driven treatment customized for each patient.

Tempus is also using deep learning techniques to predict which tumors might respond favorably to immunotherapy treatment.

Tempus is also using deep learning techniques to predict which tumors might respond favorably to immunotherapy treatment. Credit: Tempus

Tempus has leveraged its power and money to swing a number of deals, such as a licensing agreement with the American Society of Clinical Oncology to extract and organize data from one million patient records, according to a company profile in Forbes. Tempus reportedly works with 30% of U.S. oncologists and hopes to sequence 120,000 genomic samples for doctors this year. Last month, Tempus announced it would expand its focus to include AI diagnostics for cardiology to predict dangerous cardiac events and diseases before they occur. The effort is being done in partnership with Geisinger Health System, a regional health care provider with 1.5 million members in Pennsylvania and New Jersey.

Machine Learning for Pathology

Click for company websiteAnother company leveraging big data and AI for precision medicine in diagnostics got a big payday earlier this year. Founded in 2016, Boston-based PathAI raised $60 million in April, bringing its total disclosed funding to about $75 million. And that doesn’t include whatever global life sciences company LabCorp (LH) – probably most well known for making people pee in a cup for pre-employment screenings, another reason to live life as a self-employed digital nomad – invested in PathAI in July. The two companies are collaborating on potential clinical applications for PathAI’s technology, which digitizes pathology images and uses machine learning algorithms to analyze tumor cells pixel by pixel.

Whereas Tempus is working directly with doctors like oncologists, PathAI has been building relationships with researchers and pharmaceutical companies like Novartis (NVS), Gilead Sciences (GILD), and Bristol-Myers Squibb (BMY).

Update 11/11/19: PathAI has raised $15 million in additional Series B funding to accelerate its clinical development capabilities. This brings the company’s total funding to $90.2 million to date. 

An AI Supercomputer for Pathology

Click for company websiteFounded in 2018, Paige AI picked up $25 million in its first year of existence after spinning out of the Memorial Sloan Kettering Cancer Center in New York. The AI cancer diagnostics company is also focused on using machine learning to help pathologists make more accurate diagnostic decisions, drawing on decades of data compiled by Memorial Sloan Kettering, a cancer research center that has been around since 1884. Paige has built an AI supercomputer based on hardware from AI chip maker Nvidia (NVDA), giving it the computing power of more than 10 petaflops, which is enough to earn it a place in the top 500 supercomputers in the world. In one recent study, Paige trained neural networks on the biggest dataset to date to detect prostate cancer, achieving “near perfect accuracy” on a test set consisting of nearly 2,000 real-world images.

The New York startup was granted “Breakthrough Designation” by the U.S. Food and Drug Administration (FDA) earlier this year, the first time a company has received the designation for AI in cancer diagnosis, putting the technology on the fast track for approval.

AI Diagnostics for Breast Cancer

We’ve written before about the significance of detecting breast cancer early, so it’s no surprise that we’ve come across a couple of companies that are focused on that part of AI cancer diagnostics. In fact, research published just this month further validated the use of AI for breast cancer diagnostics. The algorithm was trained on roughly a million mammography images and identified breast cancer with 90% accuracy when combined with analysis by radiologists.

Click for company websiteFounded in 2016, London-based Kheiron is apparently named after a centaur from Greek mythology that was known for his skill in medicine and not for the French-Iranian comedian like most of us would assume. The company took in $22 million last month, which Kheiron hopes will help it scale its machine learning platform dubbed Mia. Mia analyzes standard mammography images to help radiologists make the decision of whether or not a woman requires further evaluation. The company says the software has already shown success in a multi-center clinical study, and the new funds will help with further clinical programs in the United States and Europe, where the tech has already received limited approval.

Click for company websiteAlso founded in 2016, Bangalore-based NIRAMAI Health Analytix out of the Silicon Valley of India raised a $6 million Series A earlier this year for its breast cancer detection tech. NIRAMAI stands for Non-Invasive Risk Assessment with Machine Intelligence, which tells you all you need to know. Sort of. The platform uses a high-resolution thermal sensing device and cloud-based analytics where algorithms can detect tumors five times smaller than what a clinical exam can detect. The algorithms have been put to the test over three clinical trials involving more than 4,000 women, achieving 90% sensitivity, including a 27% higher accuracy than mammography, mainly for detecting cancers in dense breast tissue.

The Nirami SMILE web interface for detecting breast cancer.

The Niramai SMILE web interface for detecting breast cancer. Credit: Niramai

NIRAMAI also provides a web interface shoehorned into a name called Software with Machine Intelligence for Life Enhancement (SMILE) where radiologists can access results and generate reports.

AI Diagnostics for Skin Cancer

Click for company websiteSkin cancer is the most common cancer in the United States, according to the American Academy of Dermatology, which says about 9,500 people in the U.S. are diagnosed with skin cancer every day. If only someone would invent an app that could detect and track all those weird moles. Enter SkinVision, a Dutch startup founded in 2012 that has raised $12.2 million for just that purpose. Available as both an iOS and Android app, SkinVision uses a smartphone camera to take an image of a lesion that an algorithm analyzes for irregularities and other signs, returning a risk assessment, ranging from low to high, in about 30 seconds.

Screen shot of SkinVision skin cancer app.

Skin cancer: There’s an app for that. Credit: SkinVision

A study published last month gave the algorithm a passing grade with 95.1% sensitivity in detecting pre-malignant conditions. The company claims more than one million users globally.

Streamlining Pathology Workflow with AI

Click for company websiteYou’re probably starting to pick up on some trends with many of these startups that are trying to digitize cancer diagnostics and pathology using AI. It’s about streamlining and automating the process so that test results are turned around as fast as possible. That’s the motivation behind our final company on the list. Ibex Medical Analytics out of Tel Aviv, Israel was founded in 2016 and has raised $13.6 million, including an $11 million Series A in March. The company claims to have deployed the first-ever AI-based pathology cancer diagnosis system in a live clinical setting, specifically to identify missed diagnoses. In the first week on the job, the Ibex Second Read system reversed a misdiagnosis for a 55-year-old male who was told he was suffering from benign prostatic hyperplasia, which sounds pretty gruesome but simply refers to an enlarged prostate. Unfortunately, the patient actually had prostate cancer.

Heat map of cancerous tissue.

Heat map of cancerous tissue. Credit: Ibex

Last month, Ibex entered into partnership with another AI healthcare startup called Inspirata that also provides cancer pathology support to clinics. The latter company, however, actually offers a suite of different AI-powered solutions to manage cancer care from diagnostics to treatment. Will take a look at Inspirata and a new class of AI healthcare management startups in a future article.

Conclusion

Getting a fast and accurate pathology report is the most important step toward successfully diagnosing and treating cancer. It’s not only about detecting cancerous cells but determining the severity or stage of the disease. No one is talking about replacing pathologists – yet – but machine learning algorithms are quickly becoming an essential tool for augmenting the diagnostic process.

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